Radiobiology Lecture notes
Radiobiology is the branch of biology concerned with:
The effects of radiation on living organisms.
The study of biological processes using radioactive substances as tracers
There are two main points we should put into consideration to understand radiobiology:-
The first is the categories of the many variables of radiobiology, these include the following
(1)-Physical variables: e.g.
type of radiation
Energy
LET
Dose
dose rate
fractionation (partial vs whole body; acute vs chronic).
(2)-Chemical variables: e.g.
O2
H2O content
Nature of molecule
Radioprotectors
Radiosensitizers
pH and
Competing
(3) Biological variables:
Cell type
degree of differentiation,
likelihood of division,
rate of proliferation,
cell cycle stage,
repair (cellular, molecular),
inherent radiosensitivity,
tissue,
Age & sex.
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